Researchers discover gene that leads to severe weight gain with antipsychotic treatment

            Researchers at Zucker Hillside Hospital and Feinstein Institute for Medical Research found a gene that increases weight gain in those that are treated with antipsychotic drugs, used to treat psychotic disorders. In this study they used second-generation antipsychotics or SGAs, which are commonly used to treat many psychotic and non-psychotic disorders. In the study researchers first evaluated a group of patients treated for the first time with antipsychotics. Then they replicated the result in three independent groups of patients who were in psychiatric hospitals. The gene identified to increase weight gain was MC4R or melancortin-4 receptor. Originally it had been linked to obesity and type-2 diabetes. In this new study, patients gained up to 20 pounds on the treatment. 
           The article is an example of hypothesis-based science because an experiment or study was done. The study gives the possibility of being able to identify who is at great risk for severe weight gain due to the antipsychotic treatment; therefore it is helpful in relieving those who are at risk. Instead they could receive more intensive or alternative treatment that would reduce the potential for weight gain. Currently they are conducting studies to find that type of treatment.


Title of Article: Researchers discover gene that leads to severe weight gain with antipsychotic treatment
Journal: Biology News Net
Date: May 7, 2012