Jason Bryant, commonly known as "Weeman", is a living example of a genetic mutation. He suffers from achondroplasia, which is a genetic disease that doesn't allow one's arm or leg bones to grow very much. He stands at 4'7" and his love for skateboarding somehow brought him into the hit series "Jackass". Achondroplasia dwarfism comes from a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene located on chromosome 4, or it is passed down by a parent. However, if it comes from a mutation in the genes, it is an amino acid substitution that causes that gene to falter. The mutation causes the FGFR3 gene, which controls the bone growth from cartilage, particularly for longer bones (arm, leg, etc.), to not allow those bones to grow very long.

This is a hypothesis based science because scientists had to narrow the mutation down to which type of mutation it was and how it could be passed down.

This topic affects humans because it is a disease that occurs on humans and to have the knowledge of such disease brings a better understanding to the world.

Title: "Weeman", "Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome."

Author: Reality TV Online, D J Wilkin, J K Szabo, R Cameron, S Henderson, G A Bellus, M L Mack, I Kaitila, J Loughlin, A Munnich, B Sykes, J Bonaventure, and C A Francomano

Website: http://www.reality-tv-online.com/blog/weeman/, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1377389/